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PLAQUENIL (HYDROXYCHLOROQUINE SULFATE) TABLETS: MEDICATION GUIDE - MEDICAL INTERACTIONS
Plaquenil interactions with other medications
Talk to your doctor, pharmacist, or other healthcare professional if you are taking or going to take any other medications, including those obtained without prescription, vitamins and natural health products. Some medicines that may interact with Plaquenil (Hydroxychloroquine) tablets are as follows:
Digoxin. If you are taking both Plaquenil and digoxin, your doctor may decide to check the level of digoxin in your blood.
Anti-diabetic drugs. If you are taking Plaquenil and are on a medication to control diabetes mellitus [high blood sugar], there is a risk of developing unusually low blood sugar, resulting in hunger pains, rapid heart rate, dizziness, and rarely, loss of consciousness. Your doctor may decide to reduce the doses of medications to control diabetes.
Some antibiotics used for infections (aminoglycoside antibiotics) such as gentamycin, neomycin, tobramycin
Neostigmine and pyridostigmine (medicines used to treat muscle disorders)
Cimetidine (medicine used to treat heartburns)
Ciclosporine (an immunosuppressant medication)
Antacids. You should leave a gap of at least 4 hours between taking these medicines and Plaquenil (Hydroxychloroquine Sulfate)
Medicines that may affect the liver, the kidney, the skin or the eye
Medicines that may cause irregular heart beat (e.g. amiodarone, moxifloxacin) or increase the risk of convulsions (e.g. antimalarials, mefloquine)
Agalsidase (a medicine used to treat a rare genetic disease called Fabry disease)
Plaquenil has been used safely in combination with salicylates (aspirin), nonsteroidal anti-inflammatory medications, methotrexate and corticosteroids.
Plaquenil medication guide
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